Sudduth's fertile imagination has led him to paint self-portraits, dogs, television personalities, and the architecture and landscape near his home in Fayette, Alabama, as well as views of New York and other cities. In Big City Skyline, rows of people filing across a bridge toward a crowded mass of towering skyscrapers emphasize the anonymity of life in America's large cities. Sudduth's materials—mud mixed with sugar water and color extracted from weeds and vegetables—are no less inventive than his themes. He rarely uses canvases or brushes, preferring to use his fingers to paint with clay, mud, sand, and soot on plywood.